GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs11185790 | 1 | rs1075374 | chr10:91376975 | FLJ37201 | chr10:91451057-91457685:- | -0.17 | -3.74 | 0.000194 | Metabolic traits |
| BRCA | cis | rs7551732 | 1 | rs10754323 | chr1:89119492 | CCBL2 | chr1:89401456-89458643:- | 0.37 | 10.29 | 9.3E-24 | Height |
| BRCA | cis | rs9782955 | 1 | rs10754797 | chr1:236032494 | GNG4 | chr1:235710987-235814054:- | 0.18 | 4.64 | 4.0E-6 | Systemic lupus erythematosus |
| BRCA | cis | rs7637404 | 1 | rs10755146 | chr3:190985158 | UTS2D | chr3:190984945-191048325:- | -0.22 | -6.52 | 1.08E-10 | Age-related hearing impairment (interaction) |
| BRCA | cis | rs6477998 | 1 | rs10759636 | chr9:116018777 | CDC26 | chr9:116029290-116037869:- | -0.28 | -7.79 | 1.53E-14 | Hematology traits |
| BRCA | cis | rs965513 | 1 | rs10759927 | chr9:100542176 | CORO2A | chr9:100883258-100954956:- | -0.13 | -3.54 | 0.000412 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| BRCA | cis | rs965513 | 1 | rs10759927 | chr9:100542176 | NCBP1 | chr9:100395705-100436027:+ | -0.13 | -4.16 | 3.41E-5 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| BRCA | cis | rs965513 | 1 | rs10759927 | chr9:100542176 | TRIM14 | chr9:100831569-100881488:- | -0.13 | -3.54 | 0.000413 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| BRCA | cis | rs965513 | 1 | rs10759927 | chr9:100542176 | TSTD2 | chr9:100362364-100395962:- | -0.12 | -4.27 | 2.08E-5 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| BRCA | cis | rs755109 | 1 | rs10760021 | chr9:100697648 | C9orf156 | chr9:100666772-100684852:- | -0.16 | -4.51 | 7.05E-6 | Quantitative traits |
| BRCA | cis | rs881375 | 1 | rs10760118 | chr9:123641616 | LOC253039 | chr9:123605320-123616644:+ | -0.36 | -10.27 | 1.22E-23 | Rheumatoid arthritis |
| BRCA | cis | rs881375 | 1 | rs10760118 | chr9:123641616 | PSMD5 | chr9:123578334-123605206:- | -0.11 | -3.4 | 0.000698 | Rheumatoid arthritis |
| BRCA | cis | rs881375 | 1 | rs10760118 | chr9:123641616 | TRAF1 | chr9:123664672-123691479:- | 0.1 | 4.54 | 6.16E-6 | Rheumatoid arthritis |
| BRCA | cis | rs881375 | 1 | rs10760121 | chr9:123647915 | LOC253039 | chr9:123605320-123616644:+ | -0.36 | -9.84 | 6.07E-22 | Rheumatoid arthritis |
| BRCA | cis | rs881375 | 1 | rs10760121 | chr9:123647915 | TRAF1 | chr9:123664672-123691479:- | 0.11 | 5.19 | 2.47E-7 | Rheumatoid arthritis |